Sherlock Holmes-worshiping cowpokes Big Red and Old Red Amlingmeyer are back in another Old West adventure. This time they sign on as guards for the hated Southern Pacific Railroad—and quickly find themselves heading full-steam toward disaster! They’ve barely left the station when the train they’re on is robbed and the baggage man loses his head...literally. Also on board for the wild ride: a drunken Pinkerton, a mysterious beauty, a secretive Chinese doctor and a deadly swamp adder with a taste for cowboys. Will Big Red and Old Red make it to the end of the line alive? Not if the bad guys get their way!